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1994 1
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1998 4
1999 8
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2021 2
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38 results

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Page 1
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.
Chen CR, Kang Y, Siegel PM, Massagué J. Chen CR, et al. Cell. 2002 Jul 12;110(1):19-32. doi: 10.1016/s0092-8674(02)00801-2. Cell. 2002. PMID: 12150994 Free article.
We defined how, in the same context, Smad3 can also mediate transcriptional repression of the growth-promoting gene c-myc. A complex containing Smad3, the transcription factors E2F4/5 and DP1, and the corepressor p107 preexists in the cytoplasm. ...Previously known as the …
We defined how, in the same context, Smad3 can also mediate transcriptional repression of the growth-promoting gene c-myc. A complex contain …
EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis.
Wang SA, Wang YC, Chuang YP, Huang YH, Su WC, Chang WC, Hung JJ. Wang SA, et al. Oncogene. 2017 May 25;36(21):2930-2945. doi: 10.1038/onc.2016.445. Epub 2016 Dec 19. Oncogene. 2017. PMID: 27991932 Free PMC article.
In this study, several cancer-related proteins (Bax, p300, E2F4 and securin) have been proven to be substrates of ubiquitin-specific peptidase 24 (USP24), and relevance has been shown between USP24 and its substrates in samples from clinical lung cancer patients. ...The mo …
In this study, several cancer-related proteins (Bax, p300, E2F4 and securin) have been proven to be substrates of ubiquitin-specific …
Characterization and functional analysis of SMAD2 regulation in hair follicle cycle in Angora rabbits.
Bao Z, Zhao B, Hu S, Yang N, Liu M, Li J, Liang S, Zhou T, Chen Y, Wu X. Bao Z, et al. Gene. 2021 Feb 20;770:145339. doi: 10.1016/j.gene.2020.145339. Epub 2020 Dec 22. Gene. 2021. PMID: 33333220
The knockdown and overexpression of SMAD2 could regulate HF growth and development related genes, such as WNT2, FGF2, and LEF1.Furthermore, SMAD2 may upregulate TGF-beta signaling pathway-related genes, including TFDP1, E2F4, and RBL1. In conclusion, our results ind …
The knockdown and overexpression of SMAD2 could regulate HF growth and development related genes, such as WNT2, FGF2, and LEF1.Furthermore, …
Meta-analysis identifying epithelial-derived transcriptomes predicts poor clinical outcome and immune infiltrations in ovarian cancer.
Li DF, Tulahong A, Uddin MN, Zhao H, Zhang H. Li DF, et al. Math Biosci Eng. 2021 Jul 30;18(5):6527-6551. doi: 10.3934/mbe.2021324. Math Biosci Eng. 2021. PMID: 34517544 Free article.
RESULTS: We identified 1339 differentially expressed genes (DEGs) in ovarian cancer epithelia including 541upregulated and 798 downregulated genes. We identified 21 (such as E2F4, FOXM1, TFDP1, E2F1, and SIN3A) and 11 (such as JUN, DDX4, FOSL1, NOC2L, and HMGA1) mas …
RESULTS: We identified 1339 differentially expressed genes (DEGs) in ovarian cancer epithelia including 541upregulated and 798 downregulated …
Adenovirus E1A directly targets the E2F/DP-1 complex.
Pelka P, Miller MS, Cecchini M, Yousef AF, Bowdish DM, Dick F, Whyte P, Mymryk JS. Pelka P, et al. J Virol. 2011 Sep;85(17):8841-51. doi: 10.1128/JVI.00539-11. Epub 2011 Jun 29. J Virol. 2011. PMID: 21715488 Free PMC article.
Importantly, expression of E1A 13S, but not E1A 12S, led to significant enhancement of E2F4 occupancy of E2F sites of two E2F-regulated promoters. These observations identify a novel mechanism by which adenovirus deregulates the cell cycle and suggest that E1A 13S may sele …
Importantly, expression of E1A 13S, but not E1A 12S, led to significant enhancement of E2F4 occupancy of E2F sites of two E2F-regulat …
High-affinity binding of the cell cycle-regulated transcription factors E2F1 and E2F4 to benzo[a]pyrene diol epoxide-DNA adducts.
Johnson DG, Coleman A, Powell KL, MacLeod MC. Johnson DG, et al. Mol Carcinog. 1997 Oct;20(2):216-23. doi: 10.1002/(sici)1098-2744(199710)20:2<216::aid-mc8>3.0.co;2-k. Mol Carcinog. 1997. PMID: 9364211
When partially purified E2F was tested in a gel mobility-shift assay, binding to a target DNA containing two consensus E2F-binding sites was enhanced by prior modification of the DNA with BPDE. Recombinant human E2F1, E2F4, and DP1 fusion proteins were affinity purified fr …
When partially purified E2F was tested in a gel mobility-shift assay, binding to a target DNA containing two consensus E2F-binding sites was …
Deregulated E2F transcriptional activity in autonomously growing melanoma cells.
Halaban R, Cheng E, Smicun Y, Germino J. Halaban R, et al. J Exp Med. 2000 Mar 20;191(6):1005-16. doi: 10.1084/jem.191.6.1005. J Exp Med. 2000. PMID: 10727462 Free PMC article.
By gel shift analysis, we show that in mitogen-dependent normal melanocytes, external growth factors tightly controlled the levels of growth-promoting free E2F DNA binding activity, composed largely of E2F2 and E2F4, and the growth-suppressive E2F4-p130 complexes. I …
By gel shift analysis, we show that in mitogen-dependent normal melanocytes, external growth factors tightly controlled the levels of growth …
38 results